determining the VEGF-induced transcriptome and chromatin accessibility in VEGF-A-treated mesodermal progenitors by single cell RNAseq and single cell ATAC-seq, and

using beyond the state-of-the-art phosphoproteomics to pinpoint key phosphorylation events downstream of VEGF-A in the differentiation of mesodermal derivatives to VPCs and then ECs during vasculogenesis

performing extensive bioinformatics to identify signalling hubs controlling vasculogenesis

evaluate the involvement of flow/shear stress and Mural cells in the differentiation of hiPSCs to ECs via mesodermal intermediates.